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KMID : 0381120150370020173
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Genes and Genomics
2015 Volume.37 No. 2 p.173 ~ p.181
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Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study
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Hong Eun-Pyo
Park Ji-Wan
Suh Jun-Gyo
Kim Dong-Hyun
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Abstract
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High triglyceride (TG) levels are known to be associated with complex diseases such as cardiovascular disease. Here, we evaluated the effect of interactions between genetic polymorphisms and environmental factors on plasma TG levels in a Korean aging cohort. Thirty-two single nucleotide polymorphism (SNP) markers located in seven genes (ADLH2, APOE, GCKR, MC4R, TCF7L2, GATA2, and HNF1A) for TG levels were genotyped in 714 older Koreans (mean age, 68 years). We performed multiple linear regression analyses for these SNP markers under three genetic models (i.e. additive, dominant, and recessive) and evaluated their associations with multiple environmental factors, including obesity, systolic blood pressure, and drinking and smoking habits. We found evidence for four SNP-smoking interactions. The CC genotype of rs1260326 (GCKR) interacted with current smoking for lower TG levels (P G×E = 0.017). TG levels were higher in smokers with the GG genotype of rs2713604 (GATA2) than in those with the GA + AA genotypes (195.6 and 145.7 mg/dL, respectively, P G×E = 0.029). The GA + AA genotypes of rs2713603 (GATA2) were associated with elevated TG levels in smokers when compared to non-smokers carrying the GG genotype (180.6 mg/dL vs. 148.3 mg/dL, P G×E = 0.046). The C allele of rs2464196 (HNF1A) interacted with current smoking for elevated TG levels (P G×E = 0.028). The gene and cigarette smoking interactions shown in this study need to be validated in a large-scale study.
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KEYWORD
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Aging cohort, Cigarette smoking, Gene-environment interaction, Single nucleotide polymorphism, Triglycerides
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